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Article

Structural basis for the reversal of human MRP4-mediated multidrug resistance by lapatinib

26 Mar 2025

Abstract excerpt

Multidrug resistance proteins (MRPs) are one of the major mechanisms for developing cancer drug resistance. Human MRP4 (hMRP4) plays an important role in various chemotherapy-resistant cancers. Here, we show hMRP4 mediates the resistance of a broad spectrum of antitumor reagents in the cultured tumor cells, among which the cell resistance to vincristine and 5-fluorouracil is rescued by supplementing a tyrosinase...

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PMID: 40138312
DOI: 10.1016/j.celrep.2025.115466

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