Article
Electrochemiluminescent CdS Quantum Dots Biosensor for Cancer Mutation Detection at Different Positions on Linear DNA Analytes.
Analytical chemistry - 19 Sept 2023
Yang Fan, Gong JinBo, Li Ming, Jiang Xiangyang, Zhang Jiawen, Liao Meiyan, Zhang Hanfei, Tremblay Pier-Luc, Zhang Tian
Abstract excerpt
PCR-based techniques routinely employed for the detection of mutated linear DNA molecules, including circulating tumor DNA (ctDNA), require large nucleotide sections on both sides of the mutation for primer annealing. This means that DNA fragments with a mutation positioned closer to the extremities are unlikely to be detected. Thus, sensors capable of recognizing linear DNA with characteristic mutations closer...
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