Innate-like Gene Expression of Lung-Resident Memory CD8+ T Cells during Experimental Human Influenza: A Clinical Study.

doi:10.1164/rccm.202103-0620OC

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Article

Innate-like Gene Expression of Lung-Resident Memory CD8+ T Cells during Experimental Human Influenza: A Clinical Study.

American journal of respiratory and critical care medicine - 1 Oct 2021

Paterson Suzanna, Kar Satwik, Ung Seng Kuong, Gardener Zoe, Bergstrom Emma, Ascough Stephanie, Kalyan Mohini, Zyla Joanna, Maertzdorf Jeroen, Mollenkopf Hans-Joachim, Weiner January, Jozwik Agnieszka, Jarvis Hannah, Jha Akhilesh, Nicholson Bradly P, Veldman Timothy, Woods Chris W, Mallia Patrick, Kon Onn Min, Kaufmann Stefan H E, Openshaw Peter J, Chiu Christopher

Abstract excerpt

Rationale: Suboptimal vaccine immunogenicity and antigenic mismatch, compounded by poor uptake, means that influenza remains a major global disease. T cells recognizing peptides derived from conserved viral proteins could enhance vaccine-induced cross-strain protection. Objectives: To investigate the kinetics, phenotypes, and function of influenza virus-specific CD8+ resident memory T (Trm) cells in the lower...

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Identifiers

PMID: 34256007
DOI: 10.1164/rccm.202103-0620OC
PMCID: PMC8528532

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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