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Article

Dosage optimization of tacrolimus based on the glucocorticoid dose and pharmacogenetics in adult patients with systemic lupus erythematosus.

International immunopharmacology - 1 Nov 2023

Wang Cheng-Bin, Zhang Yu-Jia, Zhao Ming-Ming, Zhao Limei

Abstract excerpt

BACKGROUND: The purpose of the study was to develop a genotype-incorporated population pharmacokinetic (PPK) model of tacrolimus (TAC) in adults with systemic lupus erythematosus (SLE) to investigate the factors influencing TAC pharmacokinetics and to develop an individualized dosing regimen based on the model. In addition, a non-genotype-incorporated model was also established to assess its predictive...

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Identifiers

PMID: 37678026
DOI: 10.1016/j.intimp.2023.110866

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