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Article

Dose tailoring of tacrolimus based on a non-linear pharmacokinetic model in children with refractory nephrotic syndrome.

International immunopharmacology - 1 Sept 2021

Li Ling, Zhu Min, Li De-Yi, Guo Hong-Li, Hu Ya-Hui, Xu Ze-Yue, Jing Xia, Chen Feng, Zhao Fei, Li Yun-Man, Xu Jing, Jiao Zheng

Abstract excerpt

The population pharmacokinetics (PPK) of tacrolimus (TAC) in children with refractory nephrotic syndrome (RNS) have not been well-characterized. This study aimed to investigate the significant factors affecting the TAC PPK characteristics of children with RNS and to optimize the dosing regimen. A total of 494 concentrations from 108 children were obtained from routine therapeutic drug monitoring between 2016 and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34284341
DOI: 10.1016/j.intimp.2021.107827

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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