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Article

Pleiotropy with sex-specific traits reveals genetic aspects of sex differences in Parkinson's disease.

Brain : a journal of neurology - 1 Mar 2024

Nordengen Kaja, Cappelletti Chiara, Bahrami Shahram, Frei Oleksandr, Pihlstrøm Lasse, Henriksen Sandra Pilar, Geut Hanneke, Rozemuller Annemieke J M, van de Berg Wilma D J, Andreassen Ole A, Toft Mathias

Abstract excerpt

Parkinson's disease is an age-related neurodegenerative disorder with a higher incidence in males than females. The causes for this sex difference are unknown. Genome-wide association studies (GWAS) have identified 90 Parkinson's disease risk loci, but the genetic studies have not found sex-specific differences in allele frequency on autosomal chromosomes or sex chromosomes. Genetic variants, however, could exert...

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Identifiers

PMID: 37671566
DOI: 10.1093/brain/awad297
PMCID: PMC10907091

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