Investigation of Autosomal Genetic Sex Differences in Parkinson's Disease.

doi:10.1002/ana.26090

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Article

Investigation of Autosomal Genetic Sex Differences in Parkinson's Disease.

Annals of neurology - 1 Jul 2021

Blauwendraat Cornelis, Iwaki Hirotaka, Makarious Mary B, Bandres-Ciga Sara, Leonard Hampton L, Grenn Francis P, Lake Julie, Krohn Lynne, Tan Manuela, Kim Jonggeol J, Gibbs Jesse R, Hernandez Dena G, Ruskey Jennifer A, Pihlstrøm Lasse, Toft Mathias, van Hilten Jacobus J, Marinus Johan, Schulte Claudia, Brockmann Kathrin, Sharma Manu, Siitonen Ari, Majamaa Kari, Eerola-Rautio Johanna, Tienari Pentti J, Grosset Donald G, Lesage Suzanne, Corvol Jean-Christophe, Brice Alexis, Wood Nick, Hardy John, Gan-Or Ziv, Heutink Peter, Gasser Thomas, Morris Huw R, Noyce Alastair J, Nalls Mike A, Singleton Andrew B

Abstract excerpt

OBJECTIVE: Parkinson's disease (PD) is a complex neurodegenerative disorder. Men are on average ~ 1.5 times more likely to develop PD compared to women with European ancestry. Over the years, genomewide association studies (GWAS) have identified numerous genetic risk factors for PD, however, it is unclear whether genetics contribute to disease etiology in a sex-specific manner. METHODS: In an effort to study...

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PMID: 33901317
DOI: 10.1002/ana.26090
PMCID: PMC8422907

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