Effect of Mutation on an Aggregation-Prone Segment of p53: From Monomer to Dimer to Multimer.

Abstract excerpt

Protein aggregation and amyloid formation are implicated in many diseases as well as in other biological phenomena. Recent studies have suggested that amyloid formation of tumor suppressor p53 can lead to loss of its physiological function, resulting in accelerated cancer progression. Design of cancer therapeutics, therefore, requires understanding of the mechanism of p53 aggregation. Here, we have employed...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Molecular Dynamics Simulation
• Share to Mutation
• Share to Protein Aggregates