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Article

Impaired tissue homing by the Ikzf3N159S variant is mediated by interfering with Ikaros function.

Frontiers in immunology - 1 Jan 2023

Chang Jingjie, Yamashita Motoi, Padhi Aditya K, Zhang Kam Y J, Taniuchi Ichiro

Abstract excerpt

AIOLOS, encoded by IKZF3, is a member of the IKZF family of proteins that plays an important role in regulating late B-cell differentiation. Human individuals heterozygous for the AIOLOS p.N160S variant displayed impaired humoral immune responses as well as impaired B and T cell development. We have previously reported that a mouse strain harboring an Ikzf3N159S allele that corresponds to human IKZF3N160S...

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Identifiers

PMID: 37662955
DOI: 10.3389/fimmu.2023.1239779
PMCID: PMC10469740

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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