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Article

Dendritic cells from humans with hypomorphic mutations in IKBKG/NEMO have impaired mitogen-activated protein kinase activity.

Human mutation - 1 Mar 2011

Ma Chi A, Wang Hong-Ying, Temmerman Stephane, Zhao Yongge, Wu Liming, Hornung Ronald L, Wara Diane, Jain Ashish

Abstract excerpt

The covalent attachment of lysine 63-linked polyubiquitin to the zinc-finger domain of IKBKG/NEMO (also known as IKKγ) is necessary for full activation of NF-κB. Impairments of this biochemical mechanism explain the deleterious effects of hypomorphic NEMO mutations on NF-κB signaling function in humans suffering from X-linked ectodermal dysplasia and immunodeficiency. Nevertheless, the biological function of the...

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Source

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Identifiers

PMID: 21309033
DOI: 10.1002/humu.21439
PMCID: PMC3134100

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Dendritic cells from humans with hypomorphic mutations in IKBKG/NEMO have impaired mitogen-activated protein kinase activity.PMID 21309033Read ↗

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