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Article

African Swine Fever Virus E120R Protein Inhibits Interferon Beta Production by Interacting with IRF3 To Block Its Activation.

Journal of virology - 25 Aug 2021

Liu Huisheng, Zhu Zixiang, Feng Tao, Ma Zhao, Xue Qiao, Wu Panxue, Li Pan, Li Shasha, Yang Fan, Cao Weijun, Xue Zhaoning, Chen Hongjun, Liu Xiangtao, Zheng Haixue

Abstract excerpt

African swine fever is a devastating disease of swine caused by African swine fever virus (ASFV). The pathogenesis of the disease remains largely unknown, leaving the spread of the disease uncontrolled in many countries and regions. Here, we identified E120R, a structural protein of ASFV, as a key virulence factor and late-phase-expressed protein of the virus. E120R revealed an activity to suppress the host...

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Identifiers

PMID: 34190598
DOI: 10.1128/JVI.00824-21
PMCID: PMC8387055

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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