Article
Tissue-specific signatures of activating PIK3CA and RAS mutations in carcinosarcomas of gynecologic origin.
Gynecologic oncology - 1 Apr 2011
Growdon Whitfield B, Roussel Breton N, Scialabba Vanessa L, Foster Rosemary, Dias-Santagata Dora, Iafrate A John, Ellisen Leif W, Tambouret Rosemary H, Rueda Bo R, Borger Darrell R
Abstract excerpt
OBJECTIVES: Gynecologic carcinosarcoma is an aggressive malignancy that requires more effective treatment approaches. However, therapeutic implications regarding the specific gynecologic site of origin and the admixture of carcinomatous and sarcomatous elements that define this tumor remain uncertain. Therefore, broad genotyping was performed to identify tissue-specific somatic mutational profiles that may help...
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