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Article

Clinical and Genomic Landscape of RAS Mutations in Gynecologic Cancers.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jul 2024

Son Ji, Zhang Yingao, Lin Heather, Mirallas Oriol, Alvarez Ballesteros Pablo, Nardo Mirella, Clark Natalie, Hillman R Tyler, Campbell Erick, Holla Vijaykumar, Johnson Amber M, Biter Amadeo B, Yuan Ying, Cobb Lauren P, Gershenson David M, Jazaeri Amir A, Lu Karen H, Soliman Pamela T, Westin Shannon N, Euscher Elizabeth D, Lawson Barrett C, Yang Richard K, Meric-Bernstam Funda, Hong David S

Abstract excerpt

PURPOSE: We aimed to describe RAS mutations in gynecologic cancers as they relate to clinicopathologic and genomic features, survival, and therapeutic implications. EXPERIMENTAL DESIGN: Gynecologic cancers with available somatic molecular profiling data at our institution between February 2010 and August 2022 were included and grouped by RAS mutation status. Overall survival was estimated by the Kaplan-Meier...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38687597
DOI: 10.1158/1078-0432.CCR-23-2819
PMCID: PMC11250057

Genes

KRAS
ARID1A
PIK3CA
PTEN
HRAS
NRAS
TP53

Variants

Provenance

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