Article
Extracorporeal Membrane Oxygenation-Dependent Fulminant Melioidosis From Caspase 4 Mutation Reversed by Interferon Gamma Therapy.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 25 Jan 2024
Amali Aseervatham Anusha, Ravikumar Sharada, Chew Wei Leong, Tan Zhaohong, Sam Qi Hui, Chen Kaiwen W, Boucher Dave, MacLaren Graeme, Chai Louis Yi Ann
Abstract excerpt
We describe bedside-to-bench immunological and genetic elucidation of defective pyroptosis attributable to novel caspase 4 defect mediating pathogen-triggered inflammatory programmed cell death, in the setting of severe pneumonia and abscess-forming melioidosis in an overtly healthy host failing to clear Burkholderia pseudomallei infection, and how targeted adjunctive biological therapy led to a successful outcome.
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