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Pneumolysin induced mitochondrial dysfunction leads to release of mitochondrial DNA

3 Jan 2018

Abstract excerpt

Streptococcus pneumoniae (S.pn.) is the most common bacterial pathogen causing community acquired pneumonia. The pore-forming toxin pneumolysin (PLY) is the major virulence factor of S.pn. and supposed to affect alveolar epithelial cells thereby activating the immune system by liberation of danger-associated molecular patterns (DAMP). To test this hypothesis, we established a novel live-cell imaging based assay...

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PMID: 29317705
DOI: 10.1038/s41598-017-18468-7

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