Article
Novel cholix toxin variants, ADP-ribosylating toxins in Vibrio cholerae non-O1/non-O139 strains, and their pathogenicity.
Infection and immunity - 1 Feb 2013
Awasthi Sharda Prasad, Asakura Masahiro, Chowdhury Nityananda, Neogi Sucharit Basu, Hinenoya Atsushi, Golbar Hossain M, Yamate Jyoji, Arakawa Eiji, Tada Toshiji, Ramamurthy T, Yamasaki Shinji
Abstract excerpt
Cholix toxin (ChxA) is a recently discovered exotoxin in Vibrio cholerae which has been characterized as a third member of the eukaryotic elongation factor 2-specific ADP-ribosyltransferase toxins, in addition to exotoxin A of Pseudomonas aeruginosa and diphtheria toxin of Corynebacterium diphtheriae. These toxins consist of three characteristic domains for receptor binding, translocation, and catalysis. However,...
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