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Genome-Wide Association Study Identifies Pharmacogenomic Variants Associated With Metformin Glycemic Response in African American Patients With Type 2 Diabetes.

Diabetes care - 1 Feb 2024

Wu Baojun, Yee Sook Wah, Xiao Shujie, Xu Fei, Sridhar Sneha B, Yang Mao, Hochstadt Samantha, Cabral Whitney, Lanfear David E, Hedderson Monique M, Giacomini Kathleen M, Williams L Keoki

Abstract excerpt

OBJECTIVE: Metformin is the most common treatment for type 2 diabetes (T2D). However, there have been no pharmacogenomic studies for T2D in which a population of color was used in the discovery analysis. This study sought to identify genomic variants associated with metformin response in African American patients with diabetes. RESEARCH DESIGN AND METHODS: Patients in the discovery set were adult, African...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37639712
DOI: 10.2337/dc22-2494
PMCID: PMC10834390

Genes

ARFGEF3

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