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Article

Co-evolution of AR gene copy number and structural complexity in endocrine therapy resistant prostate cancer

9 Jun 2023

Abstract excerpt

Abstract Androgen receptor (AR) inhibition is standard of care for advanced prostate cancer (PC). However, efficacy is limited by progression to castration-resistant PC (CRPC), usually due to AR re-activation via mechanisms that include AR amplification and structural rearrangement. These two classes of AR alterations often co-occur in CRPC tumors, but it is unclear whether this reflects intercellular or...

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PMID: 37636316
DOI: 10.1093/narcan/zcad045

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