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TALEN-engineered AR gene rearrangements reveal endocrine uncoupling of androgen receptor in prostate cancer

7 Oct 2013

Abstract excerpt

Androgen receptor (AR) target genes direct development and survival of the prostate epithelial lineage, including prostate cancer (PCa). Thus, endocrine therapies that inhibit the AR ligand-binding domain (LBD) are effective in treating PCa. AR transcriptional reactivation is central to resistance, as evidenced by the efficacy of AR retargeting in castration-resistant PCa (CRPC) with next-generation endocrine...

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PMID: 24101480
DOI: 10.1073/pnas.1308587110

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