Article
Repertoire and clinical hierarchy of AR locus alterations in castration-resistant prostate cancer.
Annals of oncology : official journal of the European Society for Medical Oncology - 1 Mar 2026
Virtanen T, Kwan E M, Parekh K, Bacon J V W, Huang C F, Yu I P L, Ryyppö L, Bernales C Q, Donnellan G, Tam C, Sipola J, Nikkola J, Vandekerkhove G, Tolmeijer S H, Kukkonen K, Adelia, Eigl B J, Finch D, Gagnon R, Takieldeen Y, Hardy E, Khalaf D, Kollmannsberger C, Lavoie J-M, Maurice-Dror C, Miller S, Nappi L, Noonan K, Parimi S, Riminchan A, Sartori-Mueller E, Soleimani M, Vergidis J, Zulfiqar M, Hansen A, Hotte S, Jafri M, Kolinsky M, Mukherjee S D, Ong M, Rose A A N, Tu W, Winquist E, Bergman A M, van der Zande K, Zwart W, Mehra N, van Erp N P, Zhao J L, Rathkopf D, Barbieri C E, Quigley D A, Nykter M, Lack N A, Chi K N, Annala M, Wyatt A W
Abstract excerpt
BACKGROUND: Somatic alterations to the androgen receptor (AR) gene are pivotal drivers of treatment resistance in metastatic castration-resistant prostate cancer (mCRPC), but their prevalence, clinical impact, and etiology remain incompletely understood. PATIENTS AND METHODS: We assembled a meta-cohort of 3048 plasma cell-free DNA and matched leukocyte DNA samples from 1751 mCRPC patients, accrued from eight...
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