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Article

AR gene rearrangement analysis in liquid biopsies reveals heterogeneity in lethal prostate cancer

19 Jul 2021

Abstract excerpt

Castration-resistant prostate cancer (CRPC) is driven by AR gene aberrations that arise during androgen receptor (AR)-targeted therapy. AR amplification and mutations have been profiled in circulating tumor cells (CTCs), but whether AR gene rearrangements can be assessed in CTCs is unknown. In this study, we leveraged CRPC cell lines with defined AR gene rearrangements to develop and validate a CTC DNA analysis...

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Identifiers

PMID: 34280123
DOI: 10.1530/erc-21-0157

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