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Article

Shaping the mitochondrial inner membrane in health and disease.

Journal of internal medicine - 1 Jun 2020

Colina-Tenorio L, Horten P, Pfanner N, Rampelt H

Abstract excerpt

Mitochondria play central roles in cellular energetics, metabolism and signalling. Efficient respiration, mitochondrial quality control, apoptosis and inheritance of mitochondrial DNA depend on the proper architecture of the mitochondrial membranes and a dynamic remodelling of inner membrane cristae. Defects in mitochondrial architecture can result in severe human diseases affecting predominantly the nervous...

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Identifiers

PMID: 32012363
DOI: 10.1111/joim.13031

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