Genomic Profiling Reveals Germline Predisposition and Homologous Recombination Deficiency in Pancreatic Acinar Cell Carcinoma.

doi:10.1200/JCO.23.00561

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Article

Genomic Profiling Reveals Germline Predisposition and Homologous Recombination Deficiency in Pancreatic Acinar Cell Carcinoma.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 20 Nov 2023

Mandelker Diana, Marra Antonio, Zheng-Lin Binbin, Selenica Pier, Blanco-Heredia Juan, Zhu Yingjie, Gazzo Andrea, Wong Donna, Yelskaya Zarina, Rai Vikas, Somar Joshua, Ostafi Silvana, Mehta Nikita, Yang Ciyu, Li Yirong, Brown David N, da Silva Edaise M, Pei Xin, Linkov Irina, Terraf Panieh, Misyura Maksym, Ceyhan-Birsoy Ozge, Ladanyi Marc, Berger Michael, Pareja Fresia, Stadler Zsofia, Offit Kenneth, Riaz Nadeem, Park Wungki, Chou Joanne, Capanu Marinela, Koehler Maria, Rosen Ezra, O'Reilly Eileen M, Reis-Filho Jorge S

Abstract excerpt

PURPOSE: To determine the genetic predisposition underlying pancreatic acinar cell carcinoma (PACC) and characterize its genomic features. METHODS: Both somatic and germline analyses were performed using an Food and Drug Administration-authorized matched tumor/normal sequencing assay on a clinical cohort of 28,780 patients with cancer, 49 of whom were diagnosed with PACC. For a subset of PACCs, whole-genome...

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PMID: 37607324
DOI: 10.1200/JCO.23.00561
PMCID: PMC10667000

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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