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Precision oncology promise in the management of pancreatic acinar cell carcinoma.

European journal of cancer (Oxford, England : 1990) - 5 Feb 2026

Baskar Suriya, Patel Rishi R, Gao Matthew T, Rose Brandon E, Bawek Sawyer, Vadehra Deepak, Brown Timothy J, Hornstein Nicholas J, Grewal Udhayvir S

Abstract excerpt

Pancreatic acinar cell carcinoma (PACC) is a rare malignancy, accounting for less than 2 % of all pancreatic cancers that exhibits distinct clinical and molecular features compared to the more common pancreatic ductal adenocarcinoma (PDAC). Historically, treatment approaches for PACC have been adapted from PDAC due to limited available prospective and/or randomized data to guide management. However, the emergence...

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Biomarkers, Tumor
ALK gene
CDKN2A gene
CTNNB1 gene
Molecular Targeted Therapy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Pancreatic Neoplasms

Precision Medicine

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PMID: 41518684
DOI: 10.1016/j.ejca.2026.116223

Genes

ALK
APC
ATM
BRAF
BRCA1
CDKN2A
CTNNB1
KRAS
TP53

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