Article
Comparative Genomic Analysis of Pancreatic Acinar Cell Carcinoma (PACC) and Pancreatic Ductal Adenocarcinoma (PDAC) Unveils New Actionable Genomic Aberrations in PACC.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Sept 2023
Florou Vaia, Elliott Andrew, Bailey Matthew H, Stone David, Affolter Kajsa, Soares Heloisa P, Nevala-Plagemann Chris, Scaife Courtney, Walker Phillip, Korn W Michael, Lou Emil, Shroff Rachna T, Hosein Peter J, Garrido-Laguna Ignacio
Abstract excerpt
PURPOSE: Pure pancreatic acinar cell carcinomas (PACC) are rare malignancies with no established treatment. PACC demonstrates significant genetic intertumoral heterogeneity with multiple pathways involved, suggesting using targeted cancer therapeutics to treat this disease. We aggregated one of the largest datasets of pure PACC to examine the genomic variability and explore patient-specific therapeutic targets....
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