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Article

Methods for the purification and detection of single nucleotide KRAS mutations on extrachromosomal circular DNA in human plasma.

Cancer medicine - 1 Sept 2023

Bøllehuus Hansen Lasse, Jakobsen Sandra Fugl, Zole Egija, Noer Julie Boertmann, Fang Li Tai, Alizadeh Sefa, Johansen Julia Sidenius, Mohiyuddin Marghoob, Regenberg Birgitte

Abstract excerpt

BACKGROUNDS: Despite recent advances, many cancers are still detected too late for curative treatment. There is, therefore, a need for the development of new diagnostic methods and biomarkers. One approach may arise from the detection of extrachromosomal circular DNA (eccDNA), which is part of cell-free DNA in human plasma. AIMS: First, we assessed and compared two methods for the purification of eccDNA from...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 37602814
DOI: 10.1002/cam4.6385
PMCID: PMC10523981

Genes

KRAS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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