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Article

A genetic variation in fucosyltransferase 8 accelerates HIV-1 disease progression indicating a role for N-glycan fucosylation.

AIDS (London, England) - 1 Nov 2023

van Pul Lisa, Maurer Irma, Boeser-Nunnink Brigitte D M, Harskamp Agnes M, van Dort Karel A, Kootstra Neeltje A

Abstract excerpt

OBJECTIVES: Core fucosylation by fucosyltransferase 8 (FUT8) is an important posttranslational modification that impacts components of the immune system. Genetic variations in FUT8 can alter its function and could, therefore, play a role in the antiviral immune response and pathogenesis of HIV-1. This study analysed the effect of a single nucleotide polymorphism (SNP) in FUT8 on the clinical course of HIV-1...

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Source

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Identifiers

PMID: 37598360
DOI: 10.1097/QAD.0000000000003689
PMCID: PMC10552802

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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