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Accelerated Aging in HIV/AIDS: Novel Biomarkers of Senescent Human CD8+ T Cells

22 May 2013

Abstract excerpt

Clinical evaluation of immune reconstitution and health status during HIV-1 infection and anti-retroviral therapy (ART) is largely based on CD4+ T cell counts and viral load, measures that fail to take into account the CD8+ T cell subset, known to show features of accelerated aging in HIV disease. Here, we compare adenosine deaminase (ADA), glucose uptake receptor 1 (GLUT1), and leucine-rich repeat neuronal 3...

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PMID: 23717651
DOI: 10.1371/journal.pone.0064702

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