Article
Infection-associated FUT2 (Fucosyltransferase 2) genetic variation and impact on functionality assessed by in vivo studies.
Glycoconjugate journal - 1 Jan 2010
Silva Lara M, Carvalho Ana S, Guillon Patrice, Seixas Susana, Azevedo Maria, Almeida Raquel, Ruvoën-Clouet Nathalie, Reis Celso A, Le Pendu Jacques, Rocha Jorge, David Leonor
Abstract excerpt
The secretor (Se)/nonsecretor (se) histo-blood group variation depends on the action of the FUT2 enzyme and has major implications for human susceptibility to infections. To characterize the functionality of FUT2 variants, we assessed the correlation between saliva phenotypes and sequence variation at the FUT2 gene in sixty seven individuals from northern Portugal. While most non-secretor haplotypes were found to...
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