Genetically inferred birthweight, height, and puberty timing and risk of osteosarcoma.

doi:10.1016/j.canep.2023.102432

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Article

Genetically inferred birthweight, height, and puberty timing and risk of osteosarcoma.

Cancer epidemiology - 1 Oct 2024

Gianferante D Matthew, Moore Amy, Spector Logan G, Wheeler William, Yang Tianzhong, Hubbard Aubrey, Gorlick Richard, Patiño-Garcia Ana, Lecanda Fernando, Flanagan Adrienne M, Amary Fernanda, Andrulis Irene L, Wunder Jay S, Thomas David M, Ballinger Mandy L, Serra Massimo, Hattinger Claudia, Demerath Ellen, Johnson Will, Birmann Brenda M, De Vivo Immaculata, Giles Graham, Teras Lauren R, Arslan Alan, Vermeulen Roel, Sample Jeannette, Freedman Neal D, Huang Wen-Yi, Chanock Stephen J, Savage Sharon A, Berndt Sonja I, Mirabello Lisa

Abstract excerpt

INTRODUCTION: Several studies have linked increased risk of osteosarcoma with tall stature, high birthweight, and early puberty, although evidence is inconsistent. We used genetic risk scores (GRS) based on established genetic loci for these traits and evaluated associations between genetically inferred birthweight, height, and puberty timing with osteosarcoma. METHODS: Using genotype data from two genome-wide...

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Identifiers

PMID: 37596165
DOI: 10.1016/j.canep.2023.102432
PMCID: PMC10869637

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