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SF3B1 mutations in myelodysplastic syndromes: A potential therapeutic target for modulating the entire disease process

17 Mar 2023

Abstract excerpt

Myelodysplastic syndromes (MDS) are clonal hematologic malignancies characterized by ineffective hematopoiesis and dysplasia of the myeloid cell lineage and are characterized by peripheral blood cytopenia and an increased risk of transformation to acute myeloid leukemia (AML). Approximately half of the patients with MDS have somatic mutations in the spliceosome gene. Splicing Factor 3B Subunit 1A (SF3B1), the...

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PMID: 37007111
DOI: 10.3389/fonc.2023.1116438

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