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Article

PCSK9 and the nervous system: a no-brainer?

14 Aug 2023

Abstract excerpt

In the past 20 years, PCSK9 has been shown to play a pivotal role in LDL cholesterol metabolism and cardiovascular health by inducing the lysosomal degradation of the LDL receptor. PCSK9 was discovered by the cloning of genes up-regulated after apoptosis induced by serum deprivation in primary cerebellar neurons, but despite its initial identification in the brain, the precise role of PCSK9 in the nervous system...

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PMID: 37586604
DOI: 10.1016/j.jlr.2023.100426

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