Article
Ulk4 Is Essential for Ciliogenesis and CSF Flow.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 20 Jul 2016
Liu Min, Guan Zhenlong, Shen Qin, Lalor Pierce, Fitzgerald Una, O'Brien Timothy, Dockery Peter, Shen Sanbing
Abstract excerpt
UNLABELLED: Ciliopathies are an emerging class of devastating disorders with pleiotropic symptoms affecting both the central and peripheral systems and commonly associated with hydrocephalus. Even though ciliary components and three master transcriptional regulators have been identified, little is known about the signaling molecules involved. We previously identified a novel gene, Unc51-like-kinase 4 (ULK4), as a...
Topics
- Animals
- Animals, Newborn
- Brain Mapping
- Cerebral Ventricles
- Cerebrovascular Circulation
- Cilia
- Ciliopathies
- Disease Models, Animal
- Forkhead Transcription Factors
- Gene Expression Regulation