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HDAC1/2/3 are major histone desuccinylases critical for promoter desuccinylation

15 Aug 2023

Abstract excerpt

Lysine succinylation is one of the major post-translational modifications occurring on histones and is believed to have significant roles in regulating chromatin structure and function. Currently, histone desuccinylation is widely believed to be catalyzed by members of the SIRT family deacetylases. Here, we report that histone desuccinylation is in fact primarily catalyzed by the class I HDAC1/2/3. Inhibition or...

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PMID: 37580347
DOI: 10.1038/s41421-023-00573-9

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