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Structural evolution of SARS-CoV-2 omicron in human receptor recognition.

Journal of virology - 31 Aug 2023

Zhang Wei, Shi Ke, Geng Qibin, Herbst Morgan, Wang Michael, Huang Linfen, Bu Fan, Liu Bin, Aihara Hideki, Li Fang

Abstract excerpt

Understanding the evolutionary strategies of the SARS-CoV-2 omicron variant is crucial for comprehending the COVID-19 pandemic and preventing future coronavirus pandemics. In this study, we determined the crystal structures of the receptor-binding domains (RBDs) from currently circulating omicron subvariants XBB.1 and XBB.1.5 (also the emerging XBB.1.9.1), each complexed with human ACE2. We studied how individual...

Topics

Animals
Humans
Mice
Angiotensin-Converting Enzyme 2
Mutation
SARS-CoV-2
Spike Glycoprotein, Coronavirus
Evolution, Molecular

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 37578233
DOI: 10.1128/jvi.00822-23
PMCID: PMC10506476

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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