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Structural Basis for Human Receptor Recognition by SARS-CoV-2 Omicron Variant BA.1.

Journal of virology - 27 Apr 2022

Geng Qibin, Shi Ke, Ye Gang, Zhang Wei, Aihara Hideki, Li Fang

Abstract excerpt

The highly contagious and fast-spreading omicron variant of SARS-CoV-2 infects the respiratory tracts efficiently. The receptor-binding domain (RBD) of the omicron spike protein recognizes human angiotensin-converting enzyme 2 (ACE2) as its receptor and plays a critical role in the tissue tropism of SARS-CoV-2. Here, we showed that the omicron RBD (strain BA.1) binds to ACE2 more strongly than does the prototypic...

Topics

Angiotensin-Converting Enzyme 2
COVID-19
Humans
Mutation
Protein Binding
Protein Structure, Tertiary
SARS-CoV-2
Spike Glycoprotein, Coronavirus

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 35343765
DOI: 10.1128/jvi.00249-22
PMCID: PMC9044962

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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