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Article

Structural basis for mouse receptor recognition by SARS-CoV-2 omicron variant.

Proceedings of the National Academy of Sciences of the United States of America - 1 Nov 2022

Zhang Wei, Shi Ke, Geng Qibin, Ye Gang, Aihara Hideki, Li Fang

Abstract excerpt

The sudden emergence and rapid spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) omicron variant has raised questions about its animal reservoir. Here, we investigated receptor recognition of the omicron's receptor-binding domain (RBD), focusing on four of its mutations (Q493R, Q498R, N501Y, and Y505H) surrounding two mutational hotspots. These mutations have variable effects on the RBD's...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36256797
DOI: 10.1073/pnas.2206509119
PMCID: PMC9636943

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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