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Article

A multilocus genetic risk score for obesity: Association with BMI and metabolic alterations in a cohort with severe obesity.

Medicine - 11 Aug 2023

Sag Sabine Julia Maria, Mueller Stephanie, Wallner Stefan, Strack Christina, Hubauer Ute, Mohr Margareta, Zeller Judith, Loew Thomas, Rehli Michael, Wimmer Julia, Zimmermann Martina Erika, Maier Lars Siegfried, Fischer Marcus, Baessler Andrea

Abstract excerpt

Genome wide association studies have identified numerous single nucleotide polymorphisms (SNPs) associated with obesity, yet effect sizes of individual SNPs are small. Therefore, the aim of our study was to investigate whether a genetic risk score (GRS) comprising risk alleles of SNPs identified in the GIANT consortium meta-analyses shows association with body mass index (BMI) and other BMI related metabolic...

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Share to Body Mass Index
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

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Identifiers

PMID: 37565910
DOI: 10.1097/MD.0000000000034597
PMCID: PMC10419793

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