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Article

PTPN11 variant may be a prognostic indicator of IDH-wildtype glioblastoma in a comprehensive genomic profiling cohort.

Journal of neuro-oncology - 1 Aug 2023

Otani Ryohei, Ikegami Masachika, Yamada Ryoji, Yajima Hirohisa, Kawamura Shinji, Shimizu Sakura, Tanaka Shota, Takayanagi Shunsaku, Takami Hirokazu, Yamaguchi Tatsuro

Abstract excerpt

PURPOSE: Glioblastoma (GBM) is the most common type of primary malignant brain tumor and has a poor prognosis. Identifying novel targets and stratification strategies is urgently needed to improve patient survival. The present study aimed to identify clinically relevant genomic alterations in IDH-wildtype GBM using data from comprehensive genomic profiling (CGP) assays performed nationwide in Japan. METHODS: The...

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PMID: 37552362
DOI: 10.1007/s11060-023-04411-6

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