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Article

PTPRD and CNTNAP2 as markers of tumor aggressiveness in oligodendrogliomas.

Scientific reports - 18 Aug 2022

Rautajoki Kirsi J, Jaatinen Serafiina, Tiihonen Aliisa M, Annala Matti, Vuorinen Elisa M, Kivinen Anni, Rauhala Minna J, Maass Kendra K, Pajtler Kristian W, Yli-Harja Olli, Helén Pauli, Haapasalo Joonas, Haapasalo Hannu, Zhang Wei, Nykter Matti

Abstract excerpt

Oligodendrogliomas are typically associated with the most favorable prognosis among diffuse gliomas. However, many of the tumors progress, eventually leading to patient death. To characterize the changes associated with oligodendroglioma recurrence and progression, we analyzed two recurrent oligodendroglioma tumors upon diagnosis and after tumor relapse based on whole-genome and RNA sequencing. Relapsed tumors...

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Identifiers

PMID: 35982066
DOI: 10.1038/s41598-022-14977-2
PMCID: PMC9388569

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