Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Histone acetylation by HBO1 (KAT7) activates Wnt/β-catenin signaling to promote leukemogenesis in B-cell acute lymphoblastic leukemia

4 Aug 2023

Abstract excerpt

B-cell acute lymphoblastic leukemia (B-ALL) is an aggressive hematological disorder with a dismal prognosis. The dysregulation of histone acetylation is of great significance in the pathogenesis and progression of B-ALL. Regarded as a fundamental acetyltransferase gene, the role of HBO1 (lysine acetyltransferase 7/KAT7) in B-ALL has not been investigated. Herein, we found that HBO1 expression was elevated in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Lymphoblastic Leukemia research
Share to Epigenetics and DNA Methylation
Share to Histone Deacetylase Inhibitors Research

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 37542030
DOI: 10.1038/s41419-023-06019-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 11 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Histone acetylation by HBO1 (KAT7) activates Wnt/β-catenin signaling to promote leukemogenesis in B-cell acute lymphoblastic leukemiaPMID 37542030Read ↗

HBO1 promotes cell proliferation in bladder cancer via activation of Wnt/β‐catenin signalingSemantic proximity Read ↗

Histone acetylation: novel target for the treatment of acute lymphoblastic leukemiaSemantic proximity Read ↗

Histone deacetylase inhibitors: targeting epigenetic regulation in the treatment of acute leukemiaSemantic proximity Read ↗

HBO1 Suppresses Anti-Tumor Immunity of CD8⁺ T Cells in Thyroid Cancer by Recruiting BRD4 to Regulate VTCN1 ExpressionSemantic proximity Read ↗

The impact of HBO1 in ovarian cancerSemantic proximity Read ↗

HDAC3 inhibition as a therapeutic strategy in T-cell acute lymphoblastic leukemia via the TYK2-STAT1-BCL2 signaling pathwaySemantic proximity Read ↗

KAT7 is a therapeutic vulnerability of <i>MLL</i> -rearranged acute myeloid leukemiaSemantic proximity Read ↗

ZBTB7A promotes malignant phenotypes in ovarian cancer through transcriptional activation of CRLF1.Semantic proximity Read ↗

Selective Inhibition of HDAC1 and HDAC2 as a Potential Therapeutic Option for B-ALLSemantic proximity Read ↗

BRG1 promotes progression of B-cell acute lymphoblastic leukemia by disrupting PPP2R1A transcriptionSemantic proximity Read ↗

KAT7 is a genetic vulnerability of acute myeloid leukemias driven by MLL rearrangements.Semantic proximity Read ↗

Inhibition of BCL11B induces downregulation of PTK7 and results in growth retardation and apoptosis in T-cell acute lymphoblastic leukemiaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.