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Combined CRISPRi and proteomics screening reveal a cohesin-CTCF-bound allele contributing to increased expression of RUVBL1 and prostate cancer progression.

American journal of human genetics - 3 Aug 2023

Tian Yijun, Dong Dandan, Wang Zixian, Wu Lang, Park Jong Y, Wei Gong-Hong, Wang Liang

Abstract excerpt

Genome-wide association studies along with expression quantitative trait locus (eQTL) mapping have identified hundreds of single-nucleotide polymorphisms (SNPs) and their target genes in prostate cancer (PCa), yet functional characterization of these risk loci remains challenging. To screen for potential regulatory SNPs, we designed a CRISPRi library containing 9,133 guide RNAs (gRNAs) to cover 2,166 candidate...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37541187
DOI: 10.1016/j.ajhg.2023.07.003
PMCID: PMC10432188

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