Article
DPPA3-HIF1α axis controls colorectal cancer chemoresistance by imposing a slow cell-cycle phenotype.
Cell reports - 29 Aug 2023
Cuesta-Borràs Estefania, Salvans Cándida, Arqués Oriol, Chicote Irene, Ramírez Lorena, Cabellos Laia, Martínez-Quintanilla Jordi, Mur-Espinosa Alex, García-Álvarez Alejandro, Hernando Jorge, Tejedor Juan Ramón, Mirallas Oriol, Élez Elena, Fraga Mario F, Tabernero Josep, Nuciforo Paolo, Capdevila Jaume, Palmer Héctor G, Puig Isabel
Abstract excerpt
Tumor relapse is linked to rapid chemoresistance and represents a bottleneck for cancer therapy success. Engagement of a reduced proliferation state is a non-mutational mechanism exploited by cancer cells to bypass therapy-induced cell death. Through combining functional pulse-chase experiments in engineered cells and transcriptomic analyses, we identify DPPA3 as a master regulator of slow-cycling and...
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