Targeting the dependence on PIK3C3-mTORC1 signaling in dormancy-prone breast cancer cells blunts metastasis initiation

Abstract excerpt

Halting breast cancer metastatic relapses following primary tumor removal and the clinical dormant phase, remains challenging, due to a lack of specific vulnerabilities to target during dormancy. To address this, we conducted genome-wide CRISPR screens on two breast cancer cell lines with distinct dormancy properties: 4T1 (short-term dormancy) and 4T07 (prolonged dormancy). We discovered that loss of class-III PI3...

Topics

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• Autophagy in Disease and Therapy
• Breast Neoplasms
• Cancer Cells and Metastasis
• Cancer, Hypoxia, and Metabolism
• Cell Line, Tumor
• Gene Expression
• Mice
• Neoplasm Recurrence, Local

Identifiers and source

Literature Corpus work

da73f3a6-6f51-53ac-b4cd-1b6523428ce9

DOI

10.1101/2023.08.02.551681