From paradox to target: IFN-β hijacks MEK signaling to drive a cell death-evading dormant phenotype in colorectal cancer.

doi:10.1186/s13046-026-03768-6

Article

From paradox to target: IFN-β hijacks MEK signaling to drive a cell death-evading dormant phenotype in colorectal cancer.

Journal of experimental & clinical cancer research : CR - 27 Jun 2026

Zhou Yangyang, Geng Haigang, Xu Yi, Hong Yanggang, Mei Bo, Wu Huanglei, Jin Xuanxuan, Ye Mengfan, Wang Yi, Shen Zan, Zheng Zhigang, Zhu Zhenhua, Yang Xiangchou, Zhang Zizhen, Zhu Chunchao

Abstract excerpt

BACKGROUND: The high clinical recurrence rate of colorectal cancer (CRC) is driven by the survival of residual tumor cells that evade therapy-induced death by entering a dormant state. While dormancy is a recognized mechanism of treatment resistance, the molecular drivers governing this "quiescent reservoir" and its associated vulnerabilities remain poorly characterized, limiting the development of strategies to...

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Topics

Animals
Humans
Colorectal Neoplasms
Mice
Interferon-beta

From paradox to target: IFN-β hijacks MEK signaling to drive a cell death-evading dormant phenotype in colorectal cancer.

Abstract excerpt

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