Article

Plasma proteomics enhances genetic risk prediction and biological understanding of venous thromboembolism

2025-07-10

Abstract excerpt

Venous thromboembolism (VTE) involves complex genetic and molecular interactions not fully captured by current prediction tools. This study integrated a polygenic risk score (PRS) with plasma proteomics data from 44,138 UK Biobank participants to explore the molecular mechanisms underlying VTE. Associations between PRS VTE and 2,911 plasma proteins were analyzed, identifying 265 significant proteins linked to extr...

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Literature Corpus work: 0d22cb90-afb6-53ec-93d2-0da209ffbeeb
DOI: 10.1101/2025.07.09.25330850

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