Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Causal insights into the role of metabolites in venous thromboembolism pathogenesis: a metabolome-wide Mendelian randomization study.

Journal of thrombosis and haemostasis : JTH - 1 Jun 2025

Hu Wei, Bei Yun, Chen Guoquan, Xu Junjun, Yang Mingdong, Yu Lingyan, He Wei, Hu Yani, Mao Fengqian, Chen Shunan, Xu Donghang, Dai Haibin

Abstract excerpt

BACKGROUND: Venous thromboembolism (VTE) is a significant global health burden, and metabolic alterations play a key role in its pathogenesis. However, previous studies have been constrained by several limitations, hindering clarification of the causal role of metabolites. OBJECTIVES: To comprehensively evaluate the causal roles of metabolites in the pathogenesis of VTE and determine whether metabolites mediate...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biomarkers
Share to Genome-Wide Association Study

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mendelian Randomization Analysis

Share to Metabolic Networks and Pathways

Share to Metabolome

Share to Metabolomics

Share to Risk Assessment

Share to Venous Thromboembolism

Source

Identifiers

PMID: 40157505
DOI: 10.1016/j.jtha.2025.03.022

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Causal insights into the role of metabolites in venous thromboembolism pathogenesis: a metabolome-wide Mendelian randomization study.PMID 40157505Read ↗

Integrative metabolomics differentiate coronary artery disease, peripheral artery disease, and venous thromboembolism risksSemantic proximity Read ↗

Exploration of the causal relationship and mechanisms between serum albumin and venous thrombosis: a bidirectional mendelian randomization analysis and bioinformatics studySemantic proximity Read ↗

Large-scale genetic correlation scanning and causal association between deep vein thrombosis and human blood metabolites.Semantic proximity Read ↗

Proteome-wide mendelian randomization identifies causal plasma proteins in venous thromboembolism development.Semantic proximity Read ↗

Associations Between Metabolic Score for Visceral Fat and Venous Thromboembolism Among 118 619 Participants With Metabolic Syndrome: Insights From Epidemiology to Genetic Susceptibility.Semantic proximity Read ↗

A phenome-wide approach to identify causal risk factors for deep vein thrombosisSemantic proximity Read ↗

Association of lipid-lowering drugs with venous thromboembolism outcomes: a phenome-wide association study and a drug-target Mendelian randomization study.Semantic proximity Read ↗

Causal relationships between COVID-19 and venous thromboembolism: A mendelian randomization analysis.Semantic proximity Read ↗

Genome-wide cross-trait analysis and Mendelian randomization reveal a shared genetic etiology and causality between COVID-19 and venous thromboembolismSemantic proximity Read ↗

Shared genetic etiology and causality between COVID-19 and venous thromboembolism: evidence from genome-wide cross trait analysis and bi-directional Mendelian randomization studySemantic proximity Read ↗

Causal effect of the gut microbiota and metabolites on venous thromboembolism: A Mendelian randomization analysisSemantic proximity Read ↗

Acute Venous Thromboembolism Plasma and Red Blood Cell Metabolomic Profiling Reveals Potential New Early Diagnostic Biomarkers: observational clinical studySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.