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Article

Interaction of CYP3A4 with caffeine: First insights into multiple substrate binding.

The Journal of biological chemistry - 1 Sept 2023

Sevrioukova Irina F

Abstract excerpt

Human cytochrome P450 3A4 (CYP3A4) is a major drug-metabolizing enzyme that shows extreme substrate promiscuity. Moreover, its large and malleable active site can simultaneously accommodate several substrate molecules of the same or different nature, which may lead to cooperative binding and allosteric behavior. Due to difficulty of crystallization of CYP3A4-substrate complexes, it remains unknown how multiple...

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Identifiers

PMID: 37524132
DOI: 10.1016/j.jbc.2023.105117
PMCID: PMC10470200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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