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Article

Allosteric Activation of Cytochrome P450 3A4 via Progesterone Bioconjugation.

Bioconjugate chemistry - 19 Apr 2017

Polic Vanja, Auclair Karine

Abstract excerpt

Human cytochrome P450 3A4 (CYP3A4) is responsible for the metabolism of the majority of drugs. As such, it is implicated in many adverse drug-drug and food-drug interactions, and is of significant interest to the pharmaceutical industry. This enzyme is known to simultaneously bind multiple ligands and display atypical enzyme kinetics, suggestive of allostery and cooperativity. As well, evidence of a postulated...

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PMID: 28339191
DOI: 10.1021/acs.bioconjchem.6b00604

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