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Germline mechanisms of immunotherapy toxicities in the era of genome‐wide association studies

28 Jul 2023

Abstract excerpt

Cancer immunotherapy has revolutionized the treatment of advanced cancers and is quickly becoming an option for early-stage disease. By reactivating the host immune system, immunotherapy harnesses patients' innate defenses to eradicate the tumor. By putatively similar mechanisms, immunotherapy can also substantially increase the risk of toxicities or immune-related adverse events (irAEs). Severe irAEs can lead to...

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PMID: 37515388
DOI: 10.1111/imr.13253

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